fentanyl transmucosal and pentobarbital both enhance sedation. Avoid or Use Alternate Drug. Limit use to patients for whom substitute remedy possibilities are inadequate
Reserve concomitant prescribing of such drugs in sufferers for whom other treatment method possibilities are insufficient. Limit dosages and durations to the minimum amount required. Observe carefully for indications of respiratory depression and sedation.
pentobarbital will reduce the level or impact of doxorubicin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
pentobarbital will reduce the extent or impact of pimavanserin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Prevent coadministration if possible. Watch for lessened pimavanserin efficacy. An increase in pimavanserin dosage could possibly be necessary.
fentanyl transdermal and pentobarbital both raise sedation. Keep away from or Use Alternate Drug. Limit use to sufferers for whom alternative procedure options are insufficient
pentobarbital will lower the level or outcome of copyright topical by influencing hepatic enzyme CYP2B6 metabolism. Slight/Importance Mysterious.
pentobarbital will decrease the level or result of loratadine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
If a CYP3A4 inducer is discontinued inside of a client who is stabilized on buprenorphine, observe the client for overmedication.Major - Use Choice (one)buprenorphine subdermal implant and pentobarbital both increase sedation. Keep away from or Use Alternate Drug. Limit use to people for whom different procedure possibilities are insufficient
pentobarbital will lessen the level or result of trazodone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lower the extent or outcome of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Potent or moderate CYP3A4 inducers could enhance level of diazepam elimination; as a result, efficacy of diazepam can be decreased.
pentobarbital will lower the extent or influence of darunavir by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will reduce the level or impact of clarithromycin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Not known.
lasmiditan, pentobarbital. Possibly will increase effects of the other by sedation. Use Caution/Monitor. Coadministration of lasmiditan and other CNS depressant drugs, together with alcohol haven't been evaluated in scientific research. Lasmiditan may well trigger sedation, and also other click here cognitive and/or neuropsychiatric adverse reactions.
pentobarbital will reduce the extent or effect of lumefantrine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with potent CYP3A4 inducers may lead to diminished serum concentrations and lack of antimalarial efficacy